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Andhra Pradesh Children and Parents Study (APCAPS): nutritional challenges, abdominal adiposity and type 2 diabetes in Indians: parental and offspring cardio-metabolic risk: a trans-generational extension of Hyderabad nutrition trial PDF Print

Studies linking maternal characteristics and offspring outcomes are very limited as compared to the numerous studies relating birth size and outcomes within a generation. With the current “epidemic” of chronic diseases in India, with increasingly younger populations being affected, it would be of importance to study the trans-generational association and transmission of chronic disease risk, if any, to the next generation.

The objectives of the study are: 1)To examine the association between parental and offspring cardio-metabolic risk profile and to see if the mother-offspring associations are different from father-offspring associations; 2)To study if parental deprivation in childhood (assessed from socio-economic data and height and leg length of the parents) is associated with cardio-metabolic risk in the offspring, and if so, whether nutritional supplementation of mothers in pregnancy attenuates this risk; 3)To see if children born before nutritional supplementation of mothers differ from those born after, in their disease risk profile.

The is a cross-sectional study of the parents and siblings of the subjects born in an earlier controlled, randomized, clinical trial which evaluated the impact of the nutritional supplementation component of the ICDS programme in India. Parents are in the age range of 35-60 years and siblings are 16 – 30 years of age. In order to study the associations between parental anthropometry and cardiometabolic risk markers in the offspring, data including questionnaires (evaluating diet, physical activity and socio-economic status), anthropometry, body composition, arterial stiffness and carotid scan, pulmonary function tests and fasting bloods for glucose, lipids, insulin and DNA is being collected on all members of the family in study households located in 29 villages of Rangareddy District in Hyderabad, South India.

The findings from this study, if suggestive of a trans-generational influence on chronic disease risk, modulated by a nutritional intervention, will be of important relevance to public health policy.

This research is being done as part of a PhD at Bristol University under the PHFI-UKC Wellcome Trust Capacity Building Programme.

PhD Scholar: Poornima Prabhakaran
Supervisors: K. Srinath Reddy & KV Radhakrishna (India), George Davey Smith & Yoav Ben-Shlomo (UK)
  Project Duration: 2010-2013
 
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Last Modified : August 16, 2011, 10:51 am